VIRAL VECTOR PROCESS & ANALYTICAL DEVELOPMENT
Accelerate your journey to market.
Bringing excellence in process and analytical development to the rapidly growing cell & gene therapy market.
Process Development Services
At Avid, we specialize in optimizing the production of high-quality viral vectors for cell & gene therapy applications. By delivering tailored solutions that meet your unique project requirements, we ensure efficient and robust viral vector production.
Production Modes, Cell Lines, and Virus Families
Modes of Production
- Suspension
- Adherent
- Infection
- Transfection
Cell Lines
- HEK293
- PER.C6
- VERO
- 293T
- A549
- MRC5
- HeLa
- Sf9
- BHK-21
- Other Cell Lines
Virus Families
- AAV
- LV
- HSV
- Adenovirus
- Alphavirus
- Baculovirus
- Retrovirus
- Dengue
- Other Oncolytic Viruses
- Other Viral Vectors
Modes of Production
- Suspension
- Adherent
- Infection
- Transfection
Cell Lines
- HEK293
- PER.C6
- VERO
- 293T
- A549
- MRC5
- HeLa
- Sf9
- BHK-21
- Other Cell Lines
Virus Families
- AAV
- LV
- HSV
- Adenovirus
- Alphavirus
- Baculovirus
- Retrovirus
- Dengue
- Other Oncolytic Viruses
- Other Viral Vectors
Upstream Process Development Capabilities
Our aim is to create efficient upstream processes. With advanced cell culture techniques, we utilize cutting-edge bioreactor design and media optimization to enhance cell growth, improve productivity, and maximize viral yield.
- Benchtop bioreactors
- 50L & 500L single-use bioreactors
- Multi-layer vessels
Downstream Process Development Capabilities
With a focus on refining the purification of viral vectors, we ensure the efficient recovery of high-purity viral products by using advanced chromatography techniques and filtration methods.
- ÄKTA-based chromatography skids
- TFF systems
- Ultracentrifuge
Upstream Process Development Capabilities
Our aim is to create efficient upstream processes. With advanced cell culture techniques, we utilize cutting-edge bioreactor design and media optimization of growth conditions, improve productivity, and maximize viral yield.
- Benchtop bioreactors
- 50L & 500L single-use bioreactors
- Multi-layer vessels
Downstream Process Development Capabilities
With a focus on refining the purification of viral vectors, we ensure the efficient recovery of high-purity viral products by using advanced chromatography techniques and filtration methods.
- ÄKTA-based chromatography skids
- TFF systems
- Ultracentrifuge
Analytical Development Capabilities
Our analytical team specializes in developing, transferring, and qualifying a wide range of client assays. We adapt our methods to meet each project’s unique needs, offering either fully integrated services or custom analytical development. Our experts design the required assays to characterize products in line with phase-appropriate regulatory guidelines, from early-phase to commercial.
Overall, we deliver innovative, cost-effective solutions that accelerate complex molecules to market, ensuring clear project deliverables and effective communication.
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Analytical Instrumentation
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Assays for Potency & Identity
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Assays for Product-Related Impurities
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Assays for Process-Related Impurities
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Assays for Safety & Stability
Our PD/AD and QC labs are equipped with identical instrumentation, ensuring seamless tech transfer and efficient process scale-up. This alignment minimizes variability and accelerates timelines, providing a smooth transition from development to manufacturing.
- REBEL Amino Acid Analyzer
- Vi-CELL BLU Analyzer
- Biorad QX200 ddPCR system
- Thermo QuantStudio 6
- Molecular Devices ID5 plate readers
- Millipore Oasis for Bioburden
- Veolia Eclipse and TOC instruments
- Malvern ZetaSizer Ultra Red for particle size and DLS analysis
- Waters UPLC instruments
- Repligen SoloVPE
- Advanced Instruments Osmometer
- AAV Capsid Titer
- AAV Genomic Titer
- AAV Serotype
- AAV Capsid Purity and Content
- Empty/Full Ratio
- Lentivirus Physical Titer
- Adenovirus Physical Titer
- Total Protein Concentration
- Aggregates
- Particle Charge
- HEK293 Host Cell Protein
- SF9 Host Cell Protein
- Vero Host Cell Protein
- HEK293 Host Cell DNA
- SF9 Host Cell DNA
- Vero Host Cell DNA
- HEK293 Host Cell DNA Sizing
- Plasmid (kan gene)
- Avitide AVIPure AAV2
- Avitide AVIPure AAV8
- Avitide AVIPure AAV9
- CaptureSelect AAVX
- CaptureSelect AVB
- Benzonase
- Human Serum Albumin (HSA)
- Bovine Serum Albumin (BSA)
- ADCF Antifoam Irradiated
- Kanamycin
- Pluronic F68
- Transfection Reagents
- Tween-20
- Trypsin
- DMSO
- Mycoplasma (qPCR/ddPCR)
- Sterility (qPCR)
- Endotoxins
- Bioburden
- Appearance pH
- Osmolality
Analytical Instrumentation
- REBEL Amino Acid Analyzer
- Vi-CELL BLU Analyzer
- Biorad QX200 ddPCR system
- Thermo QuantStudio 6
- Molecular Devices ID5 plate readers
- Millipore Oasis for Bioburden
- Veolia Eclipse and TOC instruments
- Malvern ZetaSizer Ultra Red for particle size and DLS analysis
- Waters UPLC instruments
- Repligen SoloVPE
- Advanced Instruments Osmometer
Assays for Potency & Identity
- AAV Capsid Titer
- AAV Genomic Titer
- AAV Serotype
- AAV Capsid Purity and Content
- Empty/Full Ratio
- Lentivirus Physical Titer
- Adenovirus Physical Titer
- Total Protein Concentration
- Aggregates
- Particle Charge
Assays for Product-Related Impurities
- HEK293 Host Cell Protein
- SF9 Host Cell Protein
- Vero Host Cell Protein
- HEK293 Host Cell DNA
- SF9 Host Cell DNA
- Vero Host Cell DNA
- HEK293 Host Cell DNA Sizing
- Plasmid (kan gene)
Assays for Process-Related Impurities
- Avitide AVIPure AAV2
- Avitide AVIPure AAV8
- Avitide AVIPure AAV9
- CaptureSelect AAVX
- CaptureSelect AVB
- Benzonase
- Human Serum Albumin (HSA)
- Bovine Serum Albumin (BSA)
- ADCF Antifoam Irradiated
- Kanamycin
- Pluronic F68
- Transfection Reagents
- Tween-20
- Trypsin
- DMSO
Assays for Safety & Stability
- Mycoplasma (qPCR/ddPCR)
- Sterility (qPCR)
- Endotoxins
- Bioburden
- Appearance pH
- Osmolality
Designed to combine art and science.
Our viral vector development and manufacturing facility in Costa Mesa, California was purpose-built with the customer and product in mind. It includes state-of-the-art process and analytical development labs to accommodate the requirements of your viral vector project.
Designed to combine art and science.
Our viral vector development and manufacturing facility in Costa Mesa, California was purpose-built with the customer and product in mind. It includes state-of-the-art process and analytical development labs to accommodate the requirements of your viral vector project.
Explore our quality control capabilities.
Explore our quality control capabilities.